货号：AB15812

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuregulin-2 Antibody | AB15812 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neuregulin-2 at the C-terminus. View All» Molecular Weight: ~82 kDa observed. Possible glycolsylation with multiple isoforms (Longart M., et al.). View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of mouse Neuregulin-2. View All» Background Information: Neuregulin-2 is a member of the neuregulin (NRG) family of epidermal-growth-factor (EGF) like growth factors. Neuregulin-2 binds directly to ErbB3 and ErbB4. It is thought to activate acetylcholine receptor (AChR) transcription and in neurons has been shown to accumulate at the synaptic locale. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected Neuregulin-2 in normal human skin tissue. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Neuregulin-2 on 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P56974 View All» Entrez Gene Number: NP_001161363 View All» Gene Symbol:
  • NTAK

  • HRG2

  • NRG2

  • Don-1

  • DON1

  • pro-NRG2
    View All» Alternate Names:
    • neuregulin 2

    • pro-neuregulin-2, membrane-bound isoform

    • divergent of neuregulin-1

    • neural- and thymus-derived activator for ErbB kinases
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.SUBCELLULAR LOCATION: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note: Does not seem to be active (By similarity).Neuregulin-2: Secreted (By similarity). TISSUE SPECIFICTY: Highest expression in the brain, with lower levels in the lung. In the cerebellum, found in granule and Purkinje cells.DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity).PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form (By similarity).Extensive glycosylation precedes the proteolytic cleavage (By similarity).SEQUENCE SIMILARITIES: Belongs to the neuregulin family.Contains 1 EGF-like domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain. View All» Product Name: Anti-Neuregulin-2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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