货号：AB15644

品牌：Merck Millipore

规格：EA

目录价：￥3920.00

市场价格：￥3332.00

会员价格：￥3136.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HuD Antibody | AB15644 View All» Replaces: AB05644 is a recommended replacement for AB5971 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Antibody recognizes HuD. View All» Molecular Weight: Approx. 42 kDa View All» Immunogen: KLH-conjugated linear peptide a.a. 26-42. View All» Background Information: ELAV-like protein 4 (ELAVL4) also know as Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and consists of two N-terminal RNA recognition motifs (RRM1 and -2), a hinge region, and a C-terminal RRM (RRM3). Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. HuD is localized and expressed in brain tissue immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. HuD has been linked with the disease, paraneoplastic encephalomyelitis sensory neuropathy, which is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Tested on human, mouse, and rat. Sequence Homology 100% with rat, mouse, human, primate, dog, cow View All» Control: Human Brain lysate View All» Quality Assurance: Routinely evaluated by western blot on human brain lysateWestern Blot: View All» Purification Method: Antigen affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4) 15mM sodium chloride with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P26378 View All» Entrez Gene Number: NP_034618 View All» Gene Symbol:
  • HUD

  • PNEM

  • ELAVL4

  • OTTHUMP00000009612
    View All» Alternate Names:
    • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

    • ELAV-like 4

    • Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4

    • Hu-antigen D

    • Paraneoplastic encephalomyelitis antigen HuD
      View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P26378 # May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity).SIZE: 380 amino acids; 41760 Da SUBUNIT: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity).TISSUE SPECIFICITY: Brain.PTM: Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).DISEASE: SwissProt: P26378 # Paraneoplastic encephalomyelitis sensory neuropathy is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities. It may result from an immune response primarily directed against a small cell lung tumor antigen which is misdirected against similar antigens expressed in brain.SIMILARITY: SwissProt: P26378 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains. View All» Product Name: Anti-HuD View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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