货号：AB15566F

品牌：Merck Millipore

规格：

目录价：￥8132.00

市场价格：￥6912.20

会员价格：￥6505.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p75 Neurotrophin Receptor Antibody, FITC conjugated | AB15566F View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes p75 Neurotrophin Receptor (p75NTR, Low affinity NGF receptor). View All» Immunogen: Purified peptide from amino acids 188-203 of human p75NTR (Accession number P08138). View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: The immunogen sequence is identical in mouse. View All» Application Notes: Flow cytometry: 5-10 µg of antibody/1 x 10E6 cells. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P08138 View All» Entrez Gene Number: NM_002507.2 View All» Gene Symbol:
  • NGFR

  • p75(NTR)

  • TNFRSF16

  • Gp80-LNGFR

  • CD271
    View All» Alternate Names: p75NTR, Low affinity NGF receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. View All» UniProt Summary: FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-p75 Neurotrophin Receptor Antibody, FITC conjugated | AB15566F View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: FITC View All» Host: Rabbit View All»
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