货号：AB15518

品牌：Merck Millipore

规格：1EA

目录价：￥8785.75

市场价格：￥7467.89

会员价格：￥7028.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuronal pentraxin 1 Antibody | AB15518 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Neuronal pentraxin 1 (NPX1). View All» Immunogen: Synthetic peptide near the N-terminus of mouse NPX1 View All» Background Information: Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX1(Neuronal Pentraxin 1) a 432aa protein in mouse and rat, 430aa in human (chr 17q25). It mediates the uptake of degraded synaptic material which could play an important role in synaptic remodeling, expressed in brain. View All» Species Reactivity: Mouse View All» Species Reactivity Note: The immunogen sequence is 94% conserved in rat, and 82% in human NPX1. View All» Application Notes: Western blot: 1-10 µg/mL using ECL. Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mLELISA: 0.5-1 µg/mL using control peptide.Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q15818 View All» Entrez Gene Number: NM_002522.2 View All» Gene Symbol:

• NPTX1

• DKFZp686J2446

• MGC105123

• NP1

• NP-I
  View All» Alternate Names: NPX1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. View All» UniProt Summary: FUNCTION: SwissProt: Q15818 # May mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. Can mediate the neuronal and glial uptake of the snake venom toxin taipoxin (By similarity).COFACTOR: Binds 2 calcium ions per subunit (By similarity).SIZE: 432 amino acids; 47122 Da SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle (Potential).SIMILARITY: SwissProt: Q15818 ## Contains 1 pentaxin domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Neuronal pentraxin 1 Antibody | AB15518 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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