货号：AB15514

品牌：Merck Millipore

规格：1EA

目录价：￥4839.79

市场价格：￥4113.82

会员价格：￥3871.83

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuroligin 3 Antibody | AB15514 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Trade Name: Chemicon (Millipore) View All» Specificity: Neuroligin 3 (NLGN3) View All» Immunogen: Synthetic peptide near the C-terminus of human Neuroligin 3 View All» Background Information: Neuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1-10 μg/mL using ECL. Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 μg/mLELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in PBS with 0.1% BSA and 0.05% sodium azide View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9NZ94 View All» Entrez Gene Number: NM_018977.2 View All» Gene Symbol:

• NLGN3

• HNL3

• NL3

• AUTSX1

• ASPGX1

• KIAA1480
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry

  • ELISA
    View All» Entrez Gene Summary: This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q9NZ94 # Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia- glia or glia-neuron interactions in the developing peripheral nervous system.SIZE: 848 amino acids; 93895 Da SUBUNIT: Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta (By similarity). Probably interacts through its C- terminus with DLG4/PSD-95 third PDZ domain.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).DISEASE: SwissProt: Q9NZ94 # Defects in NLGN3 may be the cause of susceptibility to X- linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. & Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.SIMILARITY: SwissProt: Q9NZ94 ## Belongs to the type-B carboxylesterase/lipase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Neuroligin 3 Antibody | AB15514 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Host: Rabbit View All»
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