货号：AB1551

品牌：Merck Millipore

规格：50Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Metabotropic Glutamate Receptor 1α Antibody, pain, C-terminus | AB1551 View All» Replaces: AB1595 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes metabotropic glutamate receptor 1a (mGluR1a). On western blots of rat brain microsomes, the antibody labels a single band migrating at 140 kDa, corresponding to mGluR1alpha (Testa, 1998). The antibody recognizes a 140 kDa band in extracts from transfected cells expressing mGluR1alpha but not in extracts from transfected cells expressing mGluR5 (Marino, 2001). View All» Molecular Weight: 140 kDa View All» Epitope: C-terminus View All» Immunogen: Carboxy terminal peptide of rat mGluR1alpha conjugated to KLH with glutaraldehyde (PNVTYASVILRDYKQSSSTL). View All» Species Reactivity:

• Human

• Monkey

• Rat
  View All» Application Notes: Western blot: 0.25-1.0 μg/mL. Detects a band migrating at approximately 140 kDa. The use of membrane preparations and protease inhibitors is highly recommended. Immunohistochemistry: AB1551 can be used for immunocytochemistry using paraformaldehyde or paraformaldehyde/glutaraldehyde fixed tissue with light and electron microscopy. Cryostat and vibratome sections can be used with or without Triton X-100 treatment. Final concentrations recommended are 0.5-2.0 μg/mL. The antibody has not been tested for use in immunoprecipitation. However, antibodies to the carboxy termini of other glutamate receptors are very effective in immunoprecipitation. Optimal working dilutions must be determined by end user. View All» Control: Cerebellar tissue sections or homogenates View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified using the immunogen peptide. Lyophilized from PBS containing 1% BSA. View All» Storage Conditions: Maintain lyophilized material at 2–8°C or -20°C. Reconstitute to 500 μL with sterile distilled water. Store reconstituted material frozen (-20°C or -80°C) in undiluted aliquots for up to six months. Avoid repeated thawing and refreezing. Diluted antibody containing 0.1% sodium azide for Western blot analysis can be stored for several weeks and reused repeatedly. View All» UniProt Number: Q13255 View All» Entrez Gene Number: NM_000838.2 View All» Gene Symbol:
  • GRM1

  • mGluR1

  • MGLUR1A

  • GRM1A

  • mGlu1

  • MGLUR1

  • GPRC1A
    View All» Alternate Names: mGluR1alpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry (Paraffin)

    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. View All» UniProt Summary: FUNCTION: SwissProt: Q13255 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.SIZE: 1194 amino acids; 132367 Da SUBUNIT: Homodimer; disulfide-linked. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: Q13255 ## Belongs to the G-protein coupled receptor 3 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Metabotropic Glutamate Receptor 1α Antibody, pain, C-terminus | AB1551 View All» Concentration: 0.1 mg/mL after reconstitution View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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