货号：AB15504

品牌：Merck Millipore

规格：1EA

目录价：￥5542.65

市场价格：￥4711.25

会员价格：￥4434.12

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Klotho Antibody | AB15504 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Klotho View All» Immunogen: Synthetic peptide near the C-terminus of mouse Klotho. View All» Background Information: Animal models of human aging, which display the characteristic diseases associated with aging, provide insight into the cause of such diseases. Recently a transgenic mouse model, called Klotho, with several premature aging phenotypes has been described. They display premature aging phenotypes such as Osteoporosis, age related skin changes, ectopic calcifications, atrophy of genital organs and thymus, emphysema and short life span (Kuro-o et al., 1997). KL protein associated with the Klotho mutation is a 1014 amino acid long peptide. It has a putative signal sequence at its N-terminus and a single transmembrane domain near its C-terminus, which is postulated to anchor it to the membrane (Martin & Mian, 1997). The extracellular domain has two internal repeats, KL-1 and KL-2 which have 20-40% sequence identity to bacterial b-glucosidase of plants and animals and mammalian lactase glycosylceramidase suggesting a role for Klotho in sphingolipid metabolism (Martin & Mian, 1997). kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway. KL has been reported to be localized on the cell surface when expressed on Cho cells (Kuro-o et al., 1997). Human kl cDNA is expected to encode a protein of 1012 amino acids and has 86% homology to mouse kl. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Other species have not yet been tested. The immunogen sequence is 82% conserved in human and 76% in rat klotho. View All» Application Notes: Western blot: 1-10 µg/mL using ECL. Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9UEF7 View All» Entrez Gene Number:

• NM_153683.2

• NM_004795.2
  View All» Gene Symbol:
  • KL

  • klotho

  • EC 3.2.1.31 [Contains: Klotho peptide].
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. View All» UniProt Summary: FUNCTION: SwissProt: Q9UEF7 # The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity).SIZE: 1012 amino acids; 116181 Da SUBUNIT: Homodimer (By similarity).SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. & Isoform 2: Secreted.TISSUE SPECIFICITY: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.DOMAIN:SwissProt: Q9UEF7 Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 239, and the second one lacks the essential Glu active site residue at position 872.PTM: N-glycosylated (By similarity).DISEASE:SwissProt: Q9UEF7 # Defects in KL may be a cause of chronic renal failure complications.SIMILARITY: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Klotho Antibody | AB15504 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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