货号：AB15502

品牌：Merck Millipore

规格：

目录价：￥5054.00

市场价格：￥4295.90

会员价格：￥4043.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium Transporter 2 Antibody | AB15502 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Calcium transporter 2 (CaT-2, ECAC1). The immunogen sequence has no significant homology with CaT-1 or other proteins. View All» Immunogen: Synthetic peptide near the C-terminus of rat CaT-2. View All» Background Information: CaT2 (rat 723 aa; human 729 aa, chromosome 7q35) is also known as ECAC1 or TRPV5) is ~75% homologous with CAT1. In contrast to CaT-1, CaT-2 is exclusively expressed in kidney and absent in intestine, brain, heart, liver, lung, skeletal muscle, spleen, thymus, testis, adrenal gland. It co-localizes with calbindin D28K and Na+ channel exchanger 1 (NCX1). CaT-2 mediates saturable apical Ca++ uptake by the cells of distal convoluted tubule and connecting segment of nephron where active re-absorption of Ca++ takes place via transcellular route. CaT-2 has moderate abilities to transport Sr++ and Ba++. A strong inhibition of CaT-2 mediated Ca++ transport by Cd++ leads to hypercalciurea and renal stone formation. View All» Species Reactivity: Rat View All» Species Reactivity Note: Other species have not yet been tested. The immunogen sequence is 90% conserved in rabbit, 80% in human and 85% in mouse Cat-2/ECAC1-1. View All» Application Notes: Western blot: 1-10 µg/mL using ECL. However, posttranslational modification may alter its size depending upon the species and cell type. Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9NQA5 View All» Entrez Gene Number: NM_019841.4 View All» Gene Symbol:

• TRPV5

• ECaC1

• ECaC

• ECAC1

• CaT2

• TrpV5

• OTRPC3

• CAT2
  View All» Alternate Names: CaT-2, ECAC1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. View All» UniProt Summary: FUNCTION: SwissProt: Q9NQA5 # Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).SIZE: 729 amino acids; 82551 Da SUBUNIT: Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity).SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity).TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.PTM: Glycosylated (By similarity).SIMILARITY: SwissProt: Q9NQA5 ## Belongs to the transient receptor family. TrpV subfamily. & Contains 5 ANK repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Calcium Transporter 2 Antibody | AB15502 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-152251.htm
    © Merck Millipore代理AB15502 CALCIUM TRANSPORTER 2, RBX-50UG，产品报价联系微信jinshanbio