货号：AB15470

品牌：Merck Millipore

规格：EA

目录价：￥3796.00

市场价格：￥3226.60

会员价格：￥3036.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HES-1 Antibody | AB15470 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: HES-1 [Hairy 1]. By Western blot the antibody recognizes a band at ~30 kDa in mouse brain lysate. An additional band at ~50 kDa may be seen depending on sample and antibody concentration used. View All» Molecular Weight: ~30 kDa View All» Immunogen: Synthetic peptide. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1-5 μg/mL on mouse brain lysate. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q14469 View All» Entrez Gene Number: NM_005524.2 View All» Gene Symbol:

• HES1

• HES-1

• Hes1

• HRY

• HL

• HHL

• FLJ20408
  View All» Alternate Names: Hes1, hairy and enhancer of split 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. View All» UniProt Summary: FUNCTION: SwissProt: Q14469 # Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity).SIZE: 280 amino acids; 29541 Da SUBUNIT: Transcription repression requires formation of a complex with a corepressor protein (Groucho) such as TLE2 (By similarity). Interacts with SIRT1.SUBCELLULAR LOCATION: Nucleus.DOMAIN: SwissProt: Q14469 Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). & The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 Orange domain. View All» Brand Family: Chemicon View All» Product Name: Anti-HES-1 Antibody | AB15470 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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