货号：AB15458

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DASM1 Antibody | AB15458 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody reacts with the 130 kDa DASM1 protein. View All» Molecular Weight: 130 kDa View All» Epitope: 416-429 View All» Immunogen: Synthetic peptide corresponding to aa: 416-429 of human DASM1. View All» Background Information: Dasm1 contains five Ig domains and two fibronectin III domains in the extracellular N terminus, a single transmembrane domain, and an intracellular C-terminal tail with a type I PDZ domain binding motif at the end. It is highly expressed in the brain and localized at the dendrites. Suppression of Dasm1 expression in hippocampal neurons via RNA interference or expression of Dasm1 without its cytoplasmic tail specifically impairs dendrite, but not axon, outgrowth. Together with its orthologues in other species, Dasm1 defines a family of molecules likely involved specifically in dendrite arborization. View All» Species Reactivity: Rabbit View All» Species Reactivity Note: Reacts with human, mouse and rat. Other species have not been tested. View All» Application Notes: Western Blot Analysis: Antibody detected DASM1 in 10 μg of fetal (e14) mouse brain. View All» Control: Western Blot: fetal (e14) mouse brain and fetal (e16) rat brain View All» Quality Assurance: Routinely evaluated by Western Blot on fetal (e14) mouse brain cells lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Purified in PBS containing containing with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q05BQ1 View All» Entrez Gene Number: NM_001135050.1 View All» Gene Symbol:

• FP18798

• IGSF9A

• KIAA1355

• NRT1

• Nrt1

• OTTHUMP00000024411
  View All» Alternate Names:
  • Immunoglobulin superfamily member 9A

  • immunoglobulin superfamily, member 9
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Functions in dendrite outgrowth and synapse maturation. SUBUNIT: Interacts with MAGI2 and SHANK1. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Note=Enriched at the excitatory synapses in mature neurons (By similarity). TISSUE SPECIFICITY: Expressed in both cell bodies and dendrites of cortical and hippocampal neurons and also cerebellar Purkinje cells (at protein level). DEVELOPMENTAL STAGE: Detected in brain during embryonic development at least from E7.5 until E16.5. Mainly expressed within the dorsal root glanglia, trigeminal glanglia and olfactory epithelium of E10.5 embryos. Expressed to a lower extent in neuroepithelium, retina and hindgut. DOMAIN: The PDZ-binding motif mediates interactions with MAGI2 and SHANK1. SIMILARITY: Belongs to the immunoglobulin superfamily. Turtle family. SIMILARITY: Contains 2 fibronectin type-III domains. SIMILARITY: Contains 5 Ig-like (immunoglobulin-like) domains. View All» Product Name: Anti-DASM1 Antibody | AB15458 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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