货号：AB15369

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DUF1220 Antibody | AB15369 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: DUF1220. The antibody recognizes a protein of ~36 kDa in lysates from human heart, brain, spleen, and small intestine. The band can be blocked in all tissues by incubating the antibody with the immunogen peptide. By immunohistochemistry the antibody recognizes DUF1220 in the cerebellum, preferential expression was observed in Purkinje cells, where signals were restricted to cell bodies (cytoplasm) and dendrites. In addition to labeling in the cerebellum, neuron-specific DUF1220 signals were present in the cortical layers of the hippocampus. DUF1220 domains were also abundantly expressed in neurons within the neocortex (frontal, parietal, occipital, and temporal lobes) (See Popesco et al. 2006). View All» Molecular Weight: 36 kDa View All» Immunogen: Synthetic peptide from primate DUF1220. View All» Background Information: Extreme gene duplication is a major source of evolutionary novelty. A genome-wide survey of gene copy number variation among human and great ape lineages revealed that the most striking human lineage–specific amplification was due to an unknown gene, MGC8902, which is predicted to encode multiple copies of a protein domain of unknown function (DUF1220). Sequences encoding these domains are virtually all primate-specific, show signs of positive selection, and are increasingly amplified generally as a function of a species' evolutionary proximity to humans, where the greatest number of copies (212) is found. DUF1220 domains are highly expressed in brain regions associated with higher cognitive function, and in brain show neuron-specific expression preferentially in cell bodies and dendrites (Popesco et al. 2006). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1,000-1:2,500 on human brain. Immunohistochemistry on human cerebellum. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS containing approximately 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Western Blotting

• Immunohistochemistry
  View All» Brand Family: Chemicon View All» Product Name: Anti-DUF1220 Antibody | AB15369 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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