货号：AB15334

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nab2 Antibody | AB15334 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Nab2 (NGFI-A-binding protein-2, EGR-1-binding protein 2). By Western blot the antibody recognizes a band at ~57 kDa in mouse brain lysate. View All» Molecular Weight: 57 kDa View All» Immunogen: Synthetic peptide View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1:1,000-1:5,000 on extracts from mouse brain lysate. Optimal working dilutions must be determined by the end user. View All» Purification Method: Serum View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q15742 View All» Entrez Gene Number: NM_005967.3 View All» Gene Symbol:

• NAB2

• MGC75085

• MADER
  View All» Alternate Names: NGFI-A-binding protein-2, EGR-1-binding protein 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q15742 # Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).SIZE: 525 amino acids; 56594 Da SUBUNIT: Homomultimers may associate with EGR1 bound to DNA (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity).TISSUE SPECIFICITY: Widely expressed at low levels. Highly expressed in melanoma cell lines.DOMAIN:SwissProt: Q15742 The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization. & The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.SIMILARITY: Belongs to the NAB family. View All» Brand Family: Chemicon View All» Product Name: Anti-Nab2 Antibody | AB15334 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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