货号：AB15323

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nicotinic Acetylcholine Receptor α5 Antibody | AB15323 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Nicotinic Acetylcholine Receptor α5. View All» Molecular Weight: Approx. 57-70 kDa View All» Epitope: Extracellular Domain View All» Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from residues of Nicotinic Acetylcholine Receptor α5. View All» Modifications: Acetylation View All» Background Information: Nicotinic acetylcholine receptors, also known as nAChRs, belong to a family of proteins called ligand gated ion channels and are widely expressed throughout the nervous system. nAChRs are made up of 5 subunits (two α and three β). Nicotinic Acetylcholine Receptor α5 has an αx αy β combination. In the CNS, the α5 subunit is widely expressed in the CA1 area of the hippocampus which affects learning, memory, attention, anxiety, and potentially drug seeking behaviors. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Control: Rat e16 brain lysate View All» Quality Assurance: Routinely evaluated by Western Blot in rat e16 brain lysate.Western Blot Analysis: : 1:500 dilution of this lot detected Nicotinic Acetylcholine Receptor α5 on 10 µg of rat e16 brain lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 12 months. View All» UniProt Number: P43681 View All» Entrez Gene Number: NP_058774 View All» Gene Symbol:

• BFNC

• BFNC

• EBN1

• ENFL1

• FLJ95812

• NACHR

• NACHRA4

• NACRA4
  View All» Alternate Names:
  • cholinergic receptor, nicotinic, alpha 4

  • cholinergic receptor, nicotinic, alpha 4 subunit

  • cholinergic receptor, nicotinic, alpha polypeptide 4

  • neuronal nicotinic acetylcholine receptor alpha-4 subunit
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Neuronal receptor and ion channel activated by acetylcholine; mediates release of catecholamines into bloodstream View All» UniProt Summary: FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.SUBUNIT STRUCTURE: Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. INVOLVEMENT IN DISEASE: Defects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. SEQUENCE SIMILARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification] View All» Product Name: Anti-Nicotinic Acetylcholine Receptor α5 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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