货号：AB15272

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Syntenin-1 [Syndecan-binding protein 1] Antibody | AB15272 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Syntenin-1 [Syndecan-binding protein 1]. By Western blot the antibody reacts with a band at ~ 32 kDa on adult rat brain lysate. An additional band at ~ 20 kDa may also be seen depending on sample and antibody concentration used. View All» Molecular Weight: 32.4 kDa View All» Epitope: C-Terminus View All» Immunogen: Synthetic peptide near the C-terminus rat Syntenin-1. View All» Background Information: The syndecans are transmembrane proteoglycans that place structurally heterogeneous heparan sulfate chains at the cell surface and a highly conserved polypeptide in the cytoplasm. Syntenin (also known as SDCBP) is an approximately 33 kDa scaffolding protein that that binds to kainate receptor subunits via a PDZ interaction. There is extensive colocalization of syntenin and kainate receptors with particularly intense labeling for both proteins at growth cones. It is proposed that syntenin has a role both in controlling membrane organization and in determining the formation and maturation of synapses. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Application Notes: Western Blot:0.5 µg/mL of Anti-Syntenin can be detected in 10 µg of adult rat brain lysate. View All» Control: Tested on adult rat brain, mouse brain and HEK293 tissue lysate View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified Antibody in PBS with 0.1% NaN3 View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: O00560 View All» Entrez Gene Number:
  • NM_001007067.1

  • NM_001007068.1

  • NM_001007069.1

  • NM_001007070.1

  • NM_005625.3
    View All» Gene Symbol:
    • SDCBP

    • syntenin

    • MDA9

    • ST1

    • MDA-9

    • SYCL

    • TACIP18

    • Syntenin-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: O00560 # Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.SIZE: 298 amino acids; 32444 Da SUBUNIT: Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ (By similarity).SUBCELLULAR LOCATION: Cell junction, focal adhesion; Peripheral membrane protein. Cell junction, adherens junction; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Note=Mainly membrane- associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY: Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.PTM: Phosphorylated on tyrosine residues.SIMILARITY: SwissProt: O00560 ## Contains 2 PDZ (DHR) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Syntenin-1 [Syndecan-binding protein 1] Antibody | AB15272 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-152076.htm
      © Merck Millipore代理AB15272 Anti-Syntenin (rabbit polyclonal)，产品报价联系微信jinshanbio