货号：AB15244

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NXF2 Antibody | AB15244 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. AB15244 recognizes NFX2 View All» Molecular Weight: ~72 kDa View All» Epitope: a.a 395-407/408-420 View All» Immunogen: Synthetic Linear Peptide View All» Background Information: TAP/hNXF1 is a key factor that mediates general cellular mRNA export from the nucleus, and its orthologs are structurally and functionally conserved from yeast to humans. Metazoans encode additional proteins that share homology and domain organization with TAP/hNXF1, suggesting their participation in mRNA metabolism; however, the precise role(s) of these proteins is not well understood. Here, we found that the human mRNA export factor hNXF2 is specifically expressed in the brain, suggesting a brain-specific role in mRNA metabolism. To address the roles of additional NXF factors, we have identified and characterized the two Nxf genes, Nxf2 and Nxf7, which together with the TAP/hNXF1's ortholog Nxf1 comprise the murine Nxf family. Both mNXF2 and mNXF7 have a domain structure typical of the NXF family. We found that mNXF2 protein is expressed during mouse brain development. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Mouse. Reactivity with other species has not been determined. View All» Control: Adult mouse brain View All» Quality Assurance: Routinely tested by western blot on mouse brain. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified Antibody in PBS with 0.1% NaN3 View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. View All» UniProt Number: Q9GZY0 View All» Entrez Gene Number: NM_017809.3 View All» Gene Symbol:

• CT39

• FLJ20416

• OTTHUMP00000023711

• OTTHUMP00000023712

• TAPL-2

• TAPL2
  View All» Alternate Names:
  • Cancer/testis antigen 39

  • TAP like protein 2

  • TAP-like protein 2

  • nuclear RNA export factor 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Involved in the export of mRNA from the nucleus to the cytoplasm.SUBUNIT:Structure Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214.SUBCELLULAR: Nucleus › nucleoplasm. Cytoplasm. Note= Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.SPECIFICITY: Expressed almost exclusively in testis. Also expressed in several cancers.DOMAIN:The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.MiISCELLANEOUS: The RNA-binding domain is a non-canonical RNP-type domain.SIMILARITY: Belongs to the NXF family.Contains 4 LRR (leucine-rich) repeats.Contains 1 NTF2 domain.Contains 1 RRM (RNA recognition motif) domain.Contains 1 TAP-C domain.Sequence caution The sequence CAB75659.1 differs from that shown. Reason: Miscellaneous discrepancy. The sequence differs from that shown due to either intron retention or a splicing event. View All» Product Name: Anti-NXF2 Antibody | AB15244 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-152054.htm
    © Merck Millipore代理AB15244 NXF-2, RBX-100UG;已停产，产品报价联系微信jinshanbio