货号：AB15056

品牌：Merck Millipore

规格：

目录价：￥3475.00

市场价格：￥2953.75

会员价格：￥2780.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cryptochrome 2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Cryptochrome 2 [CRY-2]. By Western blot the antibody recognizes a doublet at ~67-70 kDa in mouse brain lysate. View All» Immunogen: Synthetic peptide. View All» Species Reactivity: Mouse View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8degC in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q49AN0 View All» Entrez Gene Number: NM_021117.2 View All» Gene Symbol:

• CRY2

• PHLL2

• HCRY2

• FLJ10332

• KIAA0658

• Cryptochrome-2.
  View All» Alternate Names: CRY2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q49AN0 # Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-BMAL1 E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK NPAS2-BMAL1 transcriptional activity through stabilizing the unphosphorylated form of BMAL1.COFACTOR: Binds 1 FAD per subunit (By similarity). & Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit (By similarity).SIZE: 593 amino acids; 66947 Da SUBUNIT: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3 (By similarity).SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or BMAL1.TISSUE SPECIFICITY: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, sketal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.PTM: Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-BMAL1-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.SIMILARITY: SwissProt: Q49AN0 ## Belongs to the DNA photolyase class-1 family. & Contains 1 DNA photolyase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Cryptochrome 2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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