货号：AB1431

品牌：Merck Millipore

规格：20000units

目录价：￥4601.00

市场价格：￥3910.85

会员价格：￥3680.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interferon-β Antibody | AB1431 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Human interferon beta. View All» Molecular Weight: 20 kDa View All» Immunogen: Recombinant human interferon beta expressed in E. coli View All» Background Information: Interferon beta is a globular protein consisting of 5 alpha helices with a predicted molecular weight of 20 kDa. Due to glycosylation, however, the observed molecular weight is closer to 25 kDa by SDS-PAGE. View All» Species Reactivity: Human View All» Application Notes: Interferon neutralization: 2 x 10e5 neutralization units/mL where one neutralization unit is the amount of antiserum required to neutralize one unit of human interferon beta (Hu-IFN-b) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," in J. Virol., Vol. 37, 755-758]; [Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods of Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined with respect to the international reference standard for human interferon beta provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23]. This material is prepared specifically for the effective neutralization of human interferon beta. Immunohistochemistry Western blot: 1:5000 Immunoprecipitation ELISA Optimal working dilutions must be determined by end user. View All» Control: IFN expressing cell lines View All» Purification Method: Unpurified View All» Presentation: Rabbit Serum diluited with PBS. Liquid containing no preservatives. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P05231 View All» Entrez Gene Number: NM_000600.1 View All» Gene Symbol:

• IL6

• HSF

• BSF-2

• HGF

• IL-6

• BSF2

• CDF

• IFNB2
  View All» Alternate Names: IFN-beta View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunohistochemistry

  • Immunoprecipitation

  • Neutralizing

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.SIZE: 212 amino acids; 23718 Da SUBCELLULAR LOCATION: Secreted.PTM: N- and O-glycosylated.DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Interferon-β Antibody | AB1431 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 20000 units View All» Format: Serum View All» Host: Rabbit View All»
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