货号：AB1248

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytochrome P450 Enzyme CYP1A2 Antibody | AB1248 View All» Replaces: MAB3526 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human cytochrome P450 enzyme CYP1A2 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes. By Western blot the antibody recognizes a protein with a molecular weight of approximately 54 kDa. View All» Immunogen: Synthetic peptide View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Western blot: 1:1,000-1:4,000 Immunohistochemistry on frozen and formaldehyde treated sections. Optimal working dilutions must be determined by end user. View All» Presentation: Rabbit antiserum. Liquid. No preservatives View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P05177 View All» Entrez Gene Number: NM_000761.3 View All» Gene Symbol:
  • CYP1A2

  • CP12

  • P450(PA)

  • CYPIA2

  • P

  • 350)

  • P3-450

  • P450-P3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. View All» UniProt Summary: FUNCTION: SwissProt: P05177 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen.SIZE: 515 amino acids; 58294 Da SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.TISSUE SPECIFICITY: Liver.SIMILARITY: SwissProt: P05177 ## Belongs to the cytochrome P450 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Cytochrome P450 Enzyme CYP1A2 Antibody | AB1248 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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