货号：AB12226

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RALY Antibody | AB12226 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 38 kDa observed View All» Epitope: 0 View All» Immunogen: Histidine-tagged recombinant protein corresponding to human RALY. View All» Background Information: RNA-binding protein RALY is a member of the RRM HNRPC family and contains a characteristic RRM (RNA recognition motif) domain. It is thought to participate in pre-mRNA splicing and may be a heterogenous nuclear ribonucleoprotein. Phosphorylation of RALY has been observed following damage to DNA. Expression has been observed in brain, heart, kidney, liver, lung, pancreas, and skeletal muscle. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated RALY from HepG2 cell lysate. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: 1:10,000 dilution of this antibody detected RALY on 10 µg of HepG2 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UKM9 View All» Entrez Gene Number: NP_057951 View All» Gene Symbol:
  • P542

  • HNRPCL2

  • RALY
    View All» Alternate Names:
    • RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))

    • RNA-binding protein (autoantigenic)

    • hnRNP associated with lethal yellow protein homolog

    • hnRNP core protein C-like 2

    • RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow)

    • Heterogeneous nuclear ribonucleoprotein C-like 2

    • RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow)

    • Autoantigen p542
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity).SUBUNIT STRUCTURE: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICTY: Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.6 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19 Ref.20MISCELLANEOUS: Autoantigen found in infectious mononucleosis caused by Epstein-Barr virus. An epitope recognized by B-cells, which cross-react with the BKRF1 protein (EBNA-1 nuclear protein) of Epstein-Barr virus has been identified.SEQUENCE SIMILARITIES: Belongs to the RRM HNRPC family. RALY subfamily.Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-RALY View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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