货号：AB10620

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cdc4 Antibody | AB10620 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes CDC4. View All» Immunogen: Synthetic peptide derived from an internal region of the human and mouse Cdc4 (archipelago (AGO), F-box/WD-repeat protein 7, F-box and WD-40 domain protein 7, F-box protein FBW7, FBX30 and SEL-10). View All» Background Information: The F-box protein family is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins are divided into 3 classes: FBWs containing WD-40 domains, FBLs containing leucine-rich repeats, and FBXs containing either different protein-protein interaction modules or no recognizable motifs. They constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. Cdc4 is one member of this family, which is also known as AGO, FBW7, FBX30 or SEL10. CDC4 binds directly to cyclin E and targets cyclin E for ubiquitin-mediated degradation. Cdc4 proteins of amino acid lengths varying from 553 aa to 707 aa in length have been reported. Cdc4 is an inhibitor of Notch signaling that targets Notch for ubiquitin-mediated degradation after a nuclear phosphorylation event.5,6 Cdc4 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. Thus, it may be important for Alzheimer's disease. Mutations of the CDC4 gene are detected in ovarian and breast cancer cell lines and the CDC4 gene may also be involved in the pathogenesis of human pancreatic and endometrial cancers. View All» Species Reactivity: Human View All» Species Reactivity Note: Reactivity has been confirmed with human T47D, U2-OS, MCF-7, HepG2 and HeLa cell lysates. View All» Application Notes: Western Blotting: 1-3 μg/mLImmunoprecipitation: 7 µg/reactionOptimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: This polyclonal antibody is supplied in 400 μL of phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. View All» Storage Conditions: Store at -20°C in undiluted aliquots for 1 year from date of shipment. View All» UniProt Number: Q969H0 View All» Entrez Gene Number:

• NM_001013415.1

• NM_018315.4

• NM_033632.2
  View All» Gene Symbol:
  • FBXW7

  • DKFZp686F23254

  • AGO

  • FBXW6

  • SEL-10

  • hAgo

  • CDC4

  • FBX30

  • FLJ11071

  • SEL10

  • FBW7

  • hCdc4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» Entrez Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q969H0 # Recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.SIZE: 707 amino acids; 79663 Da SUBUNIT: Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1A.SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Isoform 1 is widely expressed. Isoform 4 is expressed in brain.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE:SwissProt: Q969H0 # Defects in FBXW7 may be a cause of breast cancer.SIMILARITY: SwissProt: Q969H0 ## Contains 1 F-box domain. & Contains 7 WD repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Cdc4 Antibody | AB10620 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-151630.htm
      © Merck Millipore代理AB10620 Anti-Cdc4 Antibody;store at -20℃，产品报价联系微信jinshanbio