货号：AB10604

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TEM7 Antibody | AB10604 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes TEM7. View All» Immunogen: Synthetic peptide derived from the C-terminal region of the human TEM7 protein, which differs from dog by one conservative amino acid replacement. View All» Clone: ZMD.512 View All» Background Information: An emerging anticancer strategy is to inhibit angiogenesis, or the growth of new blood vessels into tumors. Targeting the endothelial cells of blood vessels may be widely applicable to many tumor types. Gene expression analysis of endothelial cells isolated from normal human colon tissue or from human colorectal cancers identified 46 transcripts, named tumor endothelial markers (TEM) that were significantly upregulated compared to with normal endothelium. TEMs that are expressed on the cell surface are of particular interest for future therapeutic approaches because these targets are accessible by the bloodstream. TEM7, also known as plexin domain containing-1 (PLXDC1), contains a single transmembrane domain. TEM7 is expressed in the endothelial cells of primary and metastatic colorectal, lung, pancreas, breast and brain tumors. TEM7 also plays a role as a transmembrane receptor in some neuronal cells. Recently, a novel leukocyte subset was described, which coexpresses endothelial cell markers (including TEM7) as well as dendritic cell markers and may provide a link between hematopoietic precursors and vascular development. TEM7 expression on the surface of tumor cells may be an attractive target for developing antiangiogenic cancer therapies. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse (positive controls: HCT-116, Jurkat, and SV40-transformed mouse endothelial cell lysates). Based on sequence homology, reactivity with dog is expected. View All» Application Notes: Western Blotting: 1-3 μg/mL View All» Purification Method: Immunoaffinity purified View All» Presentation: 400 μL aliquot at a concentration of 0.25 mg/mL in phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q8IUK5 View All» Entrez Gene Number: NM_020405.3 View All» Gene Symbol:
  • PLXDC1

  • TEM7

  • TEM3

  • FLJ36270

  • DKFZp686F0937

  • 2410003I07Rik

  • FLJ45632
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: SIZE: 500 amino acids; 55760 Da SUBUNIT: May interact with cortactin.SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein (Potential). & Isoform 2: Secreted (Potential). & Isoform 3: Secreted (Potential). & Isoform 4: Cytoplasm (Potential).TISSUE SPECIFICITY: Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue.PTM: N-glycosylated.SIMILARITY: SwissProt: Q8IUK5 ## Belongs to the plexin family. View All» Brand Family: Chemicon View All» Product Name: Anti-TEM7 Antibody | AB10604 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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