货号：AB10601

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VEGF-C Propeptide Antibody | AB10601 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes VEGF-C Propeptide. View All» Immunogen: A synthetic peptide derived from the C-terminal sequence of propeptide form of VEGF-C. View All» Clone: ZMD.83 View All» Background Information: Vascular endothelial growth factors (VEGF) are structurally and functionally related growth factors, that may play important roles in the formation of vascular systems during embryonic development, in regulation of capillary growth in adults, and in maintenance of normal vasculature. VEGF-C is a ligand for receptor tyrosine kinase VEGFR-3 (Flt-4), which is mainly expressed in the endothelium of lymphatic vessels. VEGF-C mRNA has been detected in human heart, lung, muscle, ovary, placenta, and small intestine. It is also detected in many malignant tumors, including breast carcinomas, squamous cell carcinomas, lymphomas, melanomas, sarcomas and ademomas. VEGF-C is synthesized as a precursor protein called prepropeptide, which undergoes a series of proteolytic steps to give the mature form of VEGFC. The prepropeptide is cleaved and forms a homo-dimer between two identical propeptides.6 This dimer is then processed to form a secretable tetramer that consists of two 29 kDa and two 31 kDa peptides, which is then secreted extracellularly and processed to produce the mature form that consists of two 21 kDa peptides. Studies suggest the 29/31 kDa form is the most prevalent form of VEGF-C in many biological systems. View All» Species Reactivity: Human View All» Species Reactivity Note: Human (positive control: U937 cells) View All» Application Notes: ELISA: 0.1-1.0 μg/mL Western Blotting: 2-5 μg/mL View All» Purification Method: Immunoaffinity purified View All» Presentation: 400 μL aliquot at a concentration of 0.25 mg/mL in phosphate buffered saline (pH 7.4) containing 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P49767 View All» Entrez Gene Number: NM_005429.2 View All» Gene Symbol:

• VEGFC

• VEGF-C

• VRP

• Flt4-L
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. View All» UniProt Summary: FUNCTION: SwissProt: P49767 # Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors.SIZE: 419 amino acids; 46883 Da SUBUNIT: Homodimer; non-covalent and antiparallel.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.PTM: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.SIMILARITY: SwissProt: P49767 ## Belongs to the PDGF/VEGF growth factor family. View All» Brand Family: Chemicon View All» Product Name: Anti-VEGF-C Propeptide Antibody | AB10601 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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