货号：AB10541

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Galectin-3 Antibody | AB10541 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the Pro64 mutation domain of Galectin-3. It is equally specific for wild-type or mutant His64 Galectin-3. View All» Molecular Weight: ~33 kDa observed View All» Epitope: Pro64 mutation domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the Pro64 mutation domain of human Galectin-3. View All» Background Information: Galectin-3 belongs to the galectin gene family, which is defined by the specificity of a carbohydrate recognition domain (CRD) for Gal/Lac. Galectin-3 expression is usually elevated in a wide range of neoplastic cell types. The galectin CRD consists of 135 amino acids. Galectin-3 is known to play a role in tumor development, apoptosis, and cell cycle progression. View All» Species Reactivity:

• Human

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. View All» Control: MG-63 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MG-63 cell lysate.Western Blot Analysis: A 1:250 dilution of this antibody detected Galectin-3 in 10 µg of MG-63 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P17931 View All» Entrez Gene Number: NP_002297 View All» Gene Symbol:
  • LGALS3

  • MAC2
    View All» Alternate Names:
    • Galectin-3

    • Gal-3

    • 35 kDa lectin

    • Carbohydrate-binding protein 35

    • CBP 35

    • Galactose-specific lectin 3

    • Galactoside-binding protein

    • GALBP

    • IgE-binding protein

    • L-31

    • Laminin-binding protein

    • Lectin L-29

    • Mac-2 antigen
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.SUBUNIT STRUCTURE: Probably forms homo- or heterodimers. Interacts with DMBT. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted. Note: Secreted by a non-classical secretory pathway and associates with the cell surface.TISSUE SPECIFICITY: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. View All» Product Name: Anti-Galectin-3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-151525.htm
      © Merck Millipore代理AB10541 Anti-Galectin-3 Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio