货号：AB10531

品牌：Merck Millipore

规格：EA

目录价：￥3890.00

市场价格：￥3306.50

会员价格：￥3112.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NR2A Antibody | AB10531 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NR2A at the C-terminus. View All» Molecular Weight: Observed as calculated at ~176 kDa View All» Epitope: C-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to rat NR2A at the C-terminus. View All» Background Information: NR2 or glutamate receptor, ionotropic, N-methyl D-aspartate 2 (NMDA2; NMDAR2) along with the NR1 subunit forms a heterodimer that make up the NMDA receptor. By alternative splicing there are various isoforms of NR2 classified as NR2A through D. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with mouse and rat. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected NR2A on 10 µg of mouse brain tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q00959 View All» Entrez Gene Number: NP_036705 View All» Gene Symbol:
  • GRIN2A

  • hNR2A

  • Glutamate

  • NMDAR2A

  • NR2A
    View All» Alternate Names:
    • N-methyl D-aspartate receptor subtype 2A

    • N-methyl-D-aspartate receptor channel, subunit epsilon-1

    • N-methyl-D-aspartate receptor subunit 2A

    • NMDA receptor subtype 2A

    • glutamate receptor, ionotropic, N-methyl D-aspartate 2A, NMDA
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: May play a role in synaptic transmission, learning and memory [RGD]. View All» UniProt Summary: FUNCTION: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with AIP1. Found in a complex with GRIN1 and GRIN3B. Interacts with HIP1 and NETO1 By similarity. Interacts with PDZ domains of INADL and DLG4. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein SEQUENCE SIMLARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. (View classification) View All» Product Name: Anti-NR2A View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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