货号：AB10518

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DARPP-32 Antibody | AB10518 View All» Replaces: AB1656 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes DARPP-32 near the N-terminus. View All» Molecular Weight: ~ 32 kDa observed View All» Epitope: Near N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse DARPP-32 near the N-terminus. View All» Background Information: Dopamine- and cAMP-regulated neuronal phosphoprotein (DARP-32) is a cytoplasmic member of the protein phosphatase inhibitor 1 family. DARP-32 is a multifunctional protein kinase and protein phosphatase regulator, depending on the site of its activation. It possesses at least four sites that can be phosphorylated. Phosphorylation by PKA at Thr34 stimulates DARP-32 to act as a protein-phosphatase-1 (PP-1) inhibitor. However, phosphorylation at Thr75 will inhibit Thr34 phosphorylation. This selective, bidirectional regulation allows DARPP-32 to have a wide range of influence on downstream physiological effectors such as: ion pumps, neurotransmitter receptors, voltage-gate ion channels, and transcriptional factors. Studies suggest that it may also have a role in the Circadian System photic pathway. Overexpression of DARPP-32 has been linked with antiapoptotic mechanisms of cancer cells and has been observed in breast, colon, esophagus, gastric, and prostate cancer tissues. View All» Species Reactivity:

• Rat

• Mouse

• Rhesus Macaque

• Canine
  View All» Species Reactivity Note: Demonstrated to react with rat and mouse. Predicted to react with rhesus monkey and canine based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.) Analysis: 1 µg/mL of this antibody from a previous lot detected DARPP-32 on 10 µg of rat brain tissue lysate.Immunoprecipitaion Analysis: 10 µg of this antibody from a previous lot immunoprecipitated DARPP-32 from rat brain RIPA lysate. View All» Control: Rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot on rat brain tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected DARPP-32 on 10 µg of rat brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q60829 View All» Entrez Gene Number: NP_659077 View All» Gene Symbol:
  • DARPP32

  • DARPP-32

  • AB9208

  • AB9206

  • AG657
    View All» Alternate Names:
    • protein phosphatase 1, regulatory (inhibitor) subunit 1B

    • dopamine and cAMP-regulated neuronal phosphoprotein 32

    • dopamine and cAMP regulated phosphoprotein

    • protein phosphatase 1 regulatory subunit 1B

    • Dopamine- and cAMP-regulated neuronal phosphoprotein

    • protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Inhibitor of protein-phosphatase 1.SUBCELLULAR LOCATION: Cytoplasm. PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein (By similarity).Phosphorylation of Thr-34 is required for activity (By similarity).SEQUENCE SIMILARITIES: Belongs to the protein phosphatase inhibitor 1 family. View All» Product Name: Anti-DARPP-32 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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