货号：AB10511

品牌：Merck Millipore

规格：200Ug

目录价：￥4563.00

市场价格：￥3878.55

会员价格：￥3650.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ATG7 Antibody | AB10511 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ATG7 at the N-terminus. View All» Molecular Weight: ~75 kDa observed View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human ATG7. View All» Background Information: Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved in development, differentiation, growth regulation, and tissue remodeling in multicellular organisms. Autophagy-related protein 7 (ATG7) is an ubiquitin-like modifier-activating enzyme and is essential for multisubstrates such as ATG8-like proteins GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A. ATG 7 is also involved in ATG12 conjugation to ATG5 and ATG3. In this interaction, an ATG7-ATG3 complex plays a role in the conjugation of ATG12 to ATG5. Recently, ATG7 deficiency has been linked to human breast cancer resistance to anti-cancer therapies. View All» Species Reactivity:

• Human

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with rhesus macaque, orangutan, bovine, canine, and yeast based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected ATG7 in vascular and high grade prostate carcinoma tissues. View All» Control: Human lymph node tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human lymph node tissue lysate.Western Blot Analysis: 5 µg/mL of this antibody detected ATG7 in 10 µg of human lymph node tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95352 View All» Entrez Gene Number: NP_001129503 View All» Gene Symbol:
  • APG7-LIKE

  • APG7-like

  • APG7L

  • GSA7

  • hAGP7
    View All» Alternate Names:
    • APG7 autophagy 7-like

    • APG7 autophagy 7-like (S. cerevisiae)

    • ATG7 autophagy related 7 homolog (S. cerevisiae)

    • Ubiquitin-activating enzyme E1-like protein

    • ubiquitin activating enzyme E1-like protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy By similarity.SUBUNIT STRUCTURE:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.SUBCELLULAR LOCATION: Cytoplasm Probable. TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Ref.4DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity).SEQUENCE SIMILARITY: Belongs to the ATG7 family. View All» Product Name: Anti-ATG7 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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