货号：AB1031

品牌：Merck Millipore

规格：50Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aggrecan Antibody | AB1031 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: AB1031 is specific for mouse aggrecan; other species have not been tested. View All» Immunogen: GST fusion protein containing amino acids 1177-1326 of mouse aggrecan. View All» Background Information: Aggregating chondroitin sulfate proteoglycan or aggrecan, is one of the most studied proteoglycans. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Mouse. Expected to cross react with Human and rat. View All» Application Notes: Immunohistochemistry(Paraffin): A previous lot of this antibody was used at 10 μg/mL. See note under Protocol regarding triton X-100 treatments.Immunoprecipitation: A previous lot of this antibody was used at 5 μg/ 500 μL of cell membrane extract in PBS with inhibitors and >0.5% triton X-100. View All» Control: Cartilage, neural tube, and brain tissue. View All» Quality Assurance: Routinely evaluated by Western Blot on Mouse Brain lysates. Western Blot Analysis: 1:500 dilution of this lot detected AGGRECAN on 10 μg of Mouse Brain lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Rabbit polyclonal antigen affinity purified antibody in PBS. Anti-GST has not been adsorbed. Liquid.Note: Aggrecan is present in articular cartilage, brain, heart, and other tissues. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P16112 View All» Entrez Gene Number: NP_001126 View All» Gene Symbol:

• ACAN

• MSK16

• SEDK

• CSPCP

• AGCAN

• AGC1

• CSPG1

• CSPGCP
  View All» Alternate Names:
  • Cartilage-specific proteoglycan core protein

  • Cartilage-specific proteoglycan core protein

  • aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)

  • aggrecan proteoglycan

  • aggrecan proteoglycan

  • large aggregating proteoglycan
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. View All» UniProt Summary: FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.SIZE: 2415 amino acids; 250193 Da SUBUNIT: Interacts with FBLN1 (By similarity).SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).TISSUE SPECIFICITY: Restricted to cartilages.DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Aggrecan Antibody | AB1031 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Target / Localization: Initiation of chondrogenesis View All» Format: Affinity Purified View All» Host: Rabbit View All»
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