货号：AB10300

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CYP2A6 Antibody | AB10300 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 57kDa View All» Immunogen: Recombinant human CYP2A6 View All» Isotype: IgG2b View All» Background Information: Cytochrome P450 2A6 (CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system. It is involved in the metabolism of various xenobiotics including nicotine and cotinine. View All» Species Reactivity: Human View All» Application Notes: Suggested dilutions: Western Blot: 1:5000 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Raw rabbit serum with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: P11509 View All» Entrez Gene Number: NM_000762.4 View All» Gene Symbol:

• CYP2A6

• P450

• I.

• CPA6

• P450C2A

• P450PB

• CYP2A3

• CYP2A

• CYPIIA6
  View All» Alternate Names: Cytochrome P450 2A6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. View All» UniProt Summary: FUNCTION: SwissProt: P11509 # Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase.SIZE: 494 amino acids; 56517 Da SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.TISSUE SPECIFICITY: Liver.SIMILARITY: SwissProt: P11509 ## Belongs to the cytochrome P450 family. View All» Brand Family: Chemicon View All» Product Name: Anti-CYP2A6 Antibody | AB10300 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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