货号：AB10239

品牌：Merck Millipore

规格：EA

目录价：￥4308.00

市场价格：￥3661.80

会员价格：￥3446.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NQO-1 Antibody | AB10239 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 31 kDa View All» Epitope: G115 – K274 View All» Immunogen: Recombinant NQO-1 View All» Background Information: NAD(P)H dehydrogenase, quinone 1, also known as NQO-1, is a human gene which encodes a cytoplasmic 2-electron reductase. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). View All» Species Reactivity:

• Human

• Mouse

• Rat

• Primate
  View All» Species Reactivity Note: Human. Expected to react with mouse, rat and primate based on sequence homology. View All» Application Notes: Western Blot Analysis: A 1:5000 dilution of this lot detected baculovirus expressed recombinant NQO-1 protein. View All» Quality Assurance: Routinely evaluated by Western Blot on baculovirus expressed recombinant NQO-1. View All» Presentation: Raw rabbit serum with 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt View All» UniProt Number: P15559 View All» Entrez Gene Number: NM_000903 View All» Alternate Names:
  • NAD(P)H dehydrogenase, quinone 1

  • Menadione reductase

  • NAD(P)H menadione oxidoreductase 1, dioxin-inducible

  • NAD(P)H:Quinone acceptor oxidoreductase type 1

  • NAD(P)H:menadione oxidoreductase 1

  • NAD(P)H:quinone oxidoreductase 1

  • NAD(P)H:quinone oxireductase

  • Phylloquinone reductase

  • Quinone reductase 1

  • diaphorase (NADH/NADPH) (cytochrome b-5 reductase)

  • dioxin-inducible 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] View All» UniProt Summary: Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.Catalytic activity: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.Cofactor: FAD.Enzyme regulation: Inhibited by dicoumarol.Subunit structure: Homodimer.Subcellular location: Cytoplasm. Induction By: dioxin.Polymorphism: The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.Miscellaneous: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.Sequence similarities: Belongs to the NAD(P)H dehydrogenase (quinone) family. View All» Brand Family: Chemicon View All» Product Name: Anti-NQO-1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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