货号：AB10223

品牌：Merck Millipore

规格：

目录价：￥4027.00

市场价格：￥3422.95

会员价格：￥3221.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Scirr1 Antibody | AB10223 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the internal domain of Scirr1. View All» Molecular Weight: The observed molecular weight is 58 kDa View All» Epitope: Internal View All» Immunogen: KLH-conjugated linear peptide corresponding to the internal domain of rat Scirr1. View All» Background Information: Spinal cord injury and regeneration involves transcriptional activity of many genes, of which many remain unknown. In an experiment by Tau Liu, et al. one such differentially expressed gene, termed scirr1 (spinal cord injury and/or regeneration related gene 1) was found to act temporally and spatially in accordance with the early development sequence of the central nervous system. Although the precise function of SCIRR1 is unknown, its unique pattern of expression during early development of the CNS and up-regulation after spinal cord injury suggest that SCIRR1 should be involved in the succeeding injury and/or repair processes of the injured spinal cord. Also, the typical F-box and leucine-rich repeat (LRR) architecture of rat SCIRR1 indicate that it may play an important substrate recruiting role in the pleiotropic ubiquitin/proteasome pathway. All these make scirr1 a new interesting start to study the spinal cord injury and regeneration mechanism. View All» Species Reactivity:

• Rat

• Mouse

• Bovine

• Canine

• Horse
  View All» Species Reactivity Note: Demonstrated to react with rat and mouse. Predicted to react with cow, dog, and horse based on 100% sequence homology. View All» Application Notes: Western Blot (SNAP ID) Analysis: 1:250 dilution from a previous lot detected Scirr1 on 10 µg of rat spinal cord, E16 lysate. View All» Control: Rat Spinal Cord, E16 lysate View All» Quality Assurance: Evaluated by Western Blot in rat spinal cord, E16 lysate.Western Blot Analysis: A 1:2,500 dilution of this antibody detected Scirr1 in 10 µg of rat spinal cord, E16 lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q5MJ12 View All» Entrez Gene Number: NP_001009504 View All» Gene Symbol:
  • Scirr1

  • FBXL16

  • C16orf22

  • FBL16

  • Fbl16
    View All» Alternate Names:
    • F-box and leucine-rich repeat protein 16

    • c380A1.1 (novel protein)

    • chromosome 16 open reading frame 22
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.SUBUNIT STRUCTURE: Interacts with SKP1A and CUL1 By similarity.SEQUENCE SIMILARITIES: Contains 1 F-box domain.Contains 7 LRR (leucine-rich) repeats. View All» Product Name: Anti-Scirr1 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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