货号：AB10206

品牌：Merck Millipore

规格：100Ug

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NLK Antibody | AB10206 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptided selected from human NLK. View All» Molecular Weight: ~57 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic human NLK peptide, a.a. 459-473. View All» Background Information: NLK, or nemo-like kinase, plays a role in cell fate determination and is required for the differentiation of bone marrow stromal cells, as it acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. Nlk has also been shown to suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Recent studies indicate that NLK may also promote the survival of embryonic spinal neurons and sensory neurons. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chicken

• Canine

• Xenopus
  View All» Species Reactivity Note: Reacts with human. Comparison of sequence homology suggests that this antibody may also react with mouse, rat, chicken, canine, and xenopus; however, reactivity with other species has not been tested. View All» Application Notes: Western Blotting: Recommended working dilution is 1:5000. View All» Quality Assurance: Routinely evaluated by Western blot on Jurkat cell lysates. View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.09% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. View All» UniProt Number: Q9UBE8 View All» Entrez Gene Number: NM_016231.4→ View All» Gene Symbol:
  • DKFZp761G1211

  • EC 2.7.11.24

  • FLJ21033

  • LAK1
    View All» Alternate Names:
    • nemo like kinase

    • Protein LAK1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Activated by tyrosine and threonine phosphorylation (By similarity). SUBUNIT: Interacts with HIPK2 and MYB. INTERACTION:P10242:MYB; NbExp=1; IntAct=EBI-366978, EBI-298355;SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). PTM: Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. View All» Product Name: Anti-NLK View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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