货号：AB10198

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PHB2 Antibody | AB10198 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PHB2. View All» Molecular Weight: ~33kDa View All» Epitope: a.a. 81-95 View All» Immunogen: Synthetic peptide corresponding to a.a. 81-95 of human PHB2, conjugated to KLH. View All» Background Information: The prohibitin family of mitochondrial proteins regulate replicative lifespan. In the mitochondria, Prohibin 2 (PHB2) is thought to be involved in mitochondrial respiration activity and in aging. PHB2 translocates to the nucleus in an estrogen receptor (ER)--dependent manner, where it protects sister-chromatid cohesion in mitosis. PHB2 functions as an ER-selective coregulator that represses the activity of estrogens. PHB2 is essential for proper mitotic progression since it protects the centromeric cohesion from phosphorylation by Plk1 during early mitosis. PHB2 also reepresses transcription by recruiting histone deacetylases. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. Predicted to react with rat, ape, chimp, chicken, Xenopus, dog, cow; and Drosophila (14/15) based on sequence identity. View All» Control: HeLa or Y79 cell lysate, mouse cerebellum View All» Quality Assurance: Western Blot Analysis: 1 μg/mL of this antibody detected PHB2 on 10 μg of Y79 unstimulated lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Affinity purified rabbit polyclonal serum in 200 μl of PBS containing 0.9% Azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q99623 View All» Entrez Gene Number: NP_0092004.1 View All» Gene Symbol:
  • BAP

  • BCAP37

  • Bap37

  • D-prohibitin

  • MGC117268

  • PNAS-141

  • REA

  • p22
    View All» Alternate Names:
    • B-cell associated protein

    • B-cell receptor-associated protein BAP37

    • Repressor of estrogen receptor activity

    • Prohibitin 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Prohibitin 2, also known as PHB2 is a protein that is found in the mitochondrial inner membrane. It is often expressed in the mitochondria of HeLa cells; however, it moves to the nucleus when estrogen receptors are present. Diseases associated with this protein are the diseases of aging. (source: http://www.ihop-net.org/UniPub/iHOP/gs/96298.html) View All» UniProt Summary: Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases By similarity. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. Subunit structure: Interacts with PHB, ESR1, HDAC1 and HDAC5 By similarity. Subcellular location: Mitochondrion inner membraneBy similarity. CytoplasmBy similarity. NucleusBy similarity. Developmental stage: Levels of expression in fibroblasts decrease heterogeneously during cellular aging. Induction: Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol. Sequence similarities: Belongs to the prohibitin family View All» Product Name: Anti-PHB2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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