货号：AB10000

品牌：Merck Millipore

规格：1EA

目录价：￥5820.63

市场价格：￥4947.54

会员价格：￥4656.50

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CHIP/STUB1 Antibody | AB10000 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Immunogen: Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852. View All» Background Information: U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Control: Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung. View All» Presentation: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. View All» Storage Conditions: Store at -20°C. View All» UniProt Number: Q9UNE7 View All» Entrez Gene Number: NM_005861.2 View All» Gene Symbol:
  • STUB1

  • SDCCAG7

  • NY-CO-7

  • HSPABP2

  • UBOX1

  • CHIP
    View All» Alternate Names: CHIP, STUB1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q9UNE7 # Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.SIZE: 303 amino acids; 34856 Da SUBUNIT: Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.PTM: Auto-ubiquitinated (in vitro). & Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE:SwissProt: Q9UNE7 # Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.SIMILARITY: SwissProt: Q9UNE7 ## Contains 3 TPR repeats. & Contains 1 U-box domain. View All» Brand Family: Chemicon View All» Product Name: Anti-CHIP/STUB1 Antibody | AB10000 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Goat View All»
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