货号：46-656

品牌：Merck Millipore

规格：EA

目录价：￥3253.00

市场价格：￥2765.05

会员价格：￥2602.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Cleaved PARP MAPmate View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Product Overview: Apoptosis, programmed cell death, is a tightly controlled process involved in both embryonic development and adult homeostasis in which the body is able to rid itself of damaged or unnecessary cells without inducing an inflammatory response. This essential process is triggered by both internal (DNA damage, mitochondrial dysfunction) and external (Fas and TNF receptor) signals. Dysregulated apoptosis that results in accelerated programmed cell death has been implicated in the development of various neurological diseases, such as Alzheimer’s and Parkinson’s disease, while inhibition of apoptosis is involved in the development of autoimmune disorders and cancer. View All» Key Applications: Multiplexing View All» Application Notes: The MILLIPLEX MAP Cleaved PARP MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of cleaved PARP in cell lysates using the Luminex® 100 IS, 200, or HTS system. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. View All» UniProt Summary: FUNCTION: SwissProt: P09874 # Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.SIZE: 1014 amino acids; 113084 Da SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with ZNF423 (By similarity).SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR. & Poly-ADP-ribosylated by PARP2.SIMILARITY: SwissProt: P09874 ## Contains 1 BRCT domain. & Contains 1 PARP alpha-helical domain. & Contains 1 PARP catalytic domain. & Contains 2 PARP-type zinc fingers. MISCELLANEOUS: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. View All» Brand Family: Upstate View All» Gene Symbol:

• PARP1

• poly(ADP-ribosyl)transferase

• PARP-1

• PARP

• NAD

• pADPRT-1

• ADPRT1

• Poly

• ADPRT

• PPOL
  View All» Product Name: MILLIPLEX MAP Cleaved PARP MAPmate View All» Materials Required but Not Delivered: Assay Buffer 1 (43-010)Universal Lysis Buffer (43-040)Beadlyte cell signaling streptavidin-phycoerythrin (45-0001D)Milllipore 96-well filter plate (40-0008) View All» Analytes Available: PARP (Cleaved) View All» Configuration: Single Plex View All» Components:
  • Anti-cleaved PARP Beads

  • Anti-cleaved PARP, biotin
    View All» UniProt Number: P09874 View All» Panel Type: Cell Signaling View All» Detection Methods:
    • Fluorescent

    • Luminex xMAP
      View All» Packaging: 100 points View All» Entrez Gene Number: NM_001618 View All»
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