货号：46-628

品牌：Merck Millipore

规格：EA

目录价：￥3253.00

市场价格：￥2765.05

会员价格：￥2602.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Total IRS1 MAPmate View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Key Applications: Multiplexing View All» Application Notes: The MILLIPLEX MAP Total IRS1 MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of total IRS1 in cell lysates using the Luminex® 100 IS, 200, or HTS system. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: no gene summary given View All» UniProt Summary: FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).SIZE: 1242 amino acids; 131591 Da SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain. View All» Brand Family: Upstate View All» Storage Conditions: 1 year at 4°C View All» Gene Symbol:

• IRS1

• IRS-1

• HIRS-1
  View All» Product Name: MILLIPLEX MAP Total IRS1 MAPmate View All» Analytes Available: IRS1, IRS1 (Total) View All» Configuration: Single Plex View All» Components:
  • Anti-IRS1 Beads

  • Anti-IRS1, Biotin
    View All» UniProt Number: P35568 View All» Panel Type: Cell Signaling View All» Detection Methods:
    • Fluorescent

    • Luminex xMAP
      View All» Entrez Gene Number: NM_005544.1 View All»
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