货号：33-126

品牌：Merck Millipore

规格：1920wells

目录价：￥112687.00

市场价格：￥95783.95

会员价格：￥90149.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PIP5-Kinase HTRF Assay View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1920 wells View All» Key Applications: Kinase Assay View All» Species Reactivity:

• Human

• Mouse
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Phosphatidylinositol 4-phosphate 5-kinase type-1 alphacatalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. View All» Components:
  • Reaction Buffer (4X)

  • DM A Detection Reagent

  • DM C Detection Reagent

  • DM E Detection Reagent

  • Phosphatidylinositol 4-phosphate (1mM)

  • Phosphatidylserine (1mM)

  • Stop Reagent D
    View All» Brand Family: Upstate View All» Target Sub-Family: PI3K/PI4K View All» Storage Conditions: 12 months at -70°C View All» Detection Methods: HTRF View All» Packaging: Kit capacity: 1920 wells View All» Gene Symbol:
    • PIP5K1α

    • PIP5K1γ
      View All» Product Name: PIP5-Kinase HTRF Assay View All» Entrez Gene Number:
      • NM_001135636.1

      • NM_001195733.1
        View All» Analytes Available: PIP5 Kinase View All»
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