货号：23-054

品牌：Merck Millipore

规格：

目录价：￥6430.00

市场价格：￥5465.50

会员价格：￥5144.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MuRF1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Background Information: Muscle atrophy is a debilitating and life threatening disorder. It is associated with a number of diseases including cancer, diabetes, chronic obstructive pulmonary disease and AIDS and is a natural consequence of inactivity and aging. MuRF1 is an E3 ubiquitin ligase which has been implicated as a component of atrophy-associated proteolysis. It contains an amino terminal RING finger that mediates ubiquitin transfer along with a zinc finger and two coiled-coil domains in its central region. It is up-regulated in a number of different models of atrophy and interacts with numerous myofibrillar proteins as well as Cardiac Troponin I and Creatine Kinase. Deletion of MuRF1 in mice has been shown to inhibit skeletal muscle atrophy suggesting that it may be an important drug target for the prevention of muscle wasting. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E3 View All» Brand Family: Upstate View All» Long Description: N-terminal GST-tagged, recombinant human MuRF1 full length, expressed in E.coli. Purified using glutathione sepharose. View All» Product Name: MuRF1, active View All» Entrez Gene Number: GenBank NM_032588 View All» Alternate Names:

• E3 ubiquitin-protein ligase TRIM63

• Iris RING finger protein (IRF)

• Muscle-specific RING finger protein 1

• RING finger protein 28 (RNF28)

• Striated muscle RING zinc finger protein (SMRZ)
  View All» Purification Method: Purified using glutathione sepharose. View All»
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