货号：23-044M

品牌：Merck Millipore

规格：1EA

目录价：￥41094.42

市场价格：￥34930.26

会员价格：￥32875.54

金山科研平台，产品价格货期咨询微信：jinshanbio Description: VHL complex, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Background Information: The VHL complex is a multi-subunit ubiquitin ligase composed of VHL, Elongin B, Elongin C, Cul2 and Rbx1. The VHL protein serves as the substrate recognition component and is linked by Elongin C to a heterodimeric Cul2/Rbx1 module that functions as a potent activator of the ubiquitination of target proteins by an E2 conjugating enzyme. Elongin B interacts with the complex through Elongin C and appears to stabilize the binding of Elongin C to VHL. The primary function of the VHL complex is to regulate HIF (hypoxia inducible factor) activity by targeting the hydroxylated HIF-1α subunit for ubiquitination and rapid proteasomal degradation under normoxic conditions. It therefore plays an important role in the regulation of hypoxia-inducible genes such as the vascular endothelial growth factor (VEGF) and glucose transport-1 (Glut-1). Mutations in VHL are associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and numerous forms of renal cell carcinoma. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E3 View All» Brand Family: Upstate View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: Complex of N-terminal GST-tagged, recombinant human VHL amino acids 54-end, N-terminal GST tagged, recombinant human Elongin C, untagged, recombinant human Elongin B, N-terminal 6His tagged, recombinant human Cul2 and untagged recombinant human Rbx1 co-expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose. View All» Product Name: VHL complex, active View All» Entrez Gene Number:

• NM_000551 (VHL) (GenBank Number)

• NM_005648 (Elongin C) (GenBank Number)

• NM_007108 (Elongin B) (GenBank Number)

• NM_003591 (Cul2) (GenBank Number)

• NM_014248 (Rbx1) (GenBank Number)
  View All» Alternate Names:
  • VCB-Cul2 complex

  • ECV complex

  • CBC^VHL
    View All» Purification Method: Purified using glutathione sepharose. View All»
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