货号：23-029M

品牌：Merck Millipore

规格：

目录价：￥9833.00

市场价格：￥8358.05

会员价格：￥7866.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: UbcH5a, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Background Information: Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or an Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate. The UbcH5 family (UbcH5a, UbcH5b and UbcH5c) have been shown to be the most active class of E2 enzymes in cell extracts and are associated with the regulation of a number of transcription factors, including p53 and c-Myc. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E2 View All» Brand Family: Upstate View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: N-terminal HA, 6His-tagged, recombinant human UbcH5a full length, expressed in E.coli. Purified using immobilized metal affinity chromatography. View All» Product Name: UbcH5a, active View All» Entrez Gene Number: NM_003338 (GenBank Number) View All» Alternate Names:

• Ubiquitin-conjugating enzyme E2 D1

• Ubiquitin-protein ligase D1

• Ubiquitin-conjugating enzyme E2-17 kDa 1

• UBC4/5 homolog

• Stimulator of Fe transport (SFT)

• UbcH5

• UBE2D1
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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