货号：23-021M

品牌：Merck Millipore

规格：250Ug

目录价：￥15188.00

市场价格：￥12909.80

会员价格：￥12150.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: UBE1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Background Information: UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It is responsible for the primary ubiquitin-protein isopeptide bond formation and is a critical component for the initiation of in vitro conjugation reactions. UBE1 activates ubiquitin by the ATP dependent adenylation of its C-terminal glycine carboxyl group. This ubiquitin residue is then linked to the sulphydryl side chain moiety of a cysteine residue within UBE1 by forming a high energy thiol ester bond, liberating free AMP. There are two active sites within the UBE1 molecule allowing it to accommodate two ubiquitin molecules at one time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. The activated ubiquitin is then transferred to the lysine of target proteins via the E2/E3 conjugation cascade. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E1 View All» Brand Family: Upstate View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: N-terminal 6His-tagged, recombinant human UBE1 full length, expressed by baculovirus in Sf21 insect cells. View All» Product Name: UBE1, active View All» Entrez Gene Number: NM_003334 (GenBank Number) View All» Alternate Names:

• Ubiquitin activating enzyme E1

• Ubiquitin-like modifier-activating enzyme 1

• UBA1

• A1S9 Protein
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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