货号：21-102

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: H-Ras cDNA (wt) in pUSEamp View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 µg View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: P01112 # Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.SIZE: 189 amino acids; 21298 Da SUBUNIT: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.DISEASE: SwissProt: P01112 # Defects in HRAS are the cause of Costello syndrome [MIM:218040]; also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. & Mutations which change positions 12, 13 or 61 activate the potential of c-ras to transform cultured cells and are implicated in a variety of human tumors. & Defects in HRAS are a cause of bladder cancer [MIM:109800]. & Defects in HRAS are also the cause of oral squamous cell carcinoma (OSCC).SIMILARITY: SwissProt: P01112 ## Belongs to the small GTPase superfamily. Ras family. View All» Brand Family: Upstate View All» UniProt Number: P01112 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Gene Symbol:

• HRAS

• c-bas/has

• H-Ras-1

• N-ras

• p21ras

• c-H-ras

• RASH1

• H-RasIDX

• Ha-Ras

• K-ras

• CTLO

• HRAS1
  View All» Product Name: H-Ras cDNA (wt) in pUSEamp View All» Entrez Gene Number:
  • NM_005343.2

  • NM_176795.2
    View All»
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