货号：19-164

品牌：Merck Millipore

规格：5mg

目录价：￥1949.00

市场价格：￥1656.65

会员价格：￥1559.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HA1077 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 mg View All» Key Applications: Kinase Assay View All» Application Notes: Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. View All» UniProt Summary: FUNCTION: SwissProt: Q16513 # Exhibits a preference for highly basic protein substrates (By similarity).SIZE: 984 amino acids; 112035 Da SUBCELLULAR LOCATION: Cytoplasm (By similarity).DOMAIN:SwissProt: Q16513 The C1 domain does not bind the diacylglycerol (DAG).PTM: Autophosphorylated. & Activated by limited proteolysis with trypsin (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 1 protein kinase domain. & Contains 3 REM (Hr1) repeats. View All» Brand Family: Upstate View All» Presentation: C₁₄H₁₇N₃O₂S₂HCl View All» UniProt Number:

• O75116

• Q16513

• O75582

• P51812

• P17612

• P23443

• Q15746
  View All» Storage Conditions: 1 year at 4°C View All» Gene Symbol:
  • ROCK2

  • KIAA0619
    View All» Product Name: HA1077 View All» Entrez Gene Number: NM_004850.3 View All»
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