货号：17-499

品牌：Merck Millipore

规格：

目录价：￥4884.00

市场价格：￥4151.40

会员价格：￥3907.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Phosphorylation Explorer Pack Sample Kit View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance GuaranteedGet up to $500 Reward for Publishing View All» Trade Name: Upstate (Millipore) View All» Molecular Weight: Dependent upon the molecular weight of the tyrosine phosphorylated protein being detected. View All» Modifications: Phosphorylation View All» Clone: 4G10^® Platinum and 4A4 View All» Background Information: 4G10® PlatinumThe development of the anti-phosphotyrosine, clone 4G10® in 1989 was a monumental discovery for researchers. 4G10® was the first and is the best single monoclonal antibody for the detection tyrosine phosphorylation. 4G10® is well known for its sensitivity and its ability to detect multiple tyrosine phosphorylations on numerous substrates. It has been validated by thousands of scientific and medical researchers in virtually every application and tyrosine target over the past 2 decades. To improve on something that hundred have tried and no one has succeeded, we pooled 4G10® with the next most highly regarded anti-phosphotyrosine, clone PY20 to make 4G10® Platinum. PY20 itself is a very poor substitute for 4G10®, but its additive effect allow for a greater level of detection on more substrates that even 4G10® alone was not capable of. 4A4The identification of protein phosphorylation as a regulatory mechanism originated from studies by Fischer and Krebs in the mid 1950s that later earned them the 1992 Nobel prize. It is the major mechanism for the regulation of diverse cellular processes including cell division, protein synthesis, transcriptional regulation and neurotransmission. The steady state phosphorylation of any given substrate is governed by the opposing activities of kinases and phosphatases. It is now believed that a third of all eukaryotic cellular proteins are phosphorylated and that the majority of all phosphorylation events occur on serine and threonine residues (greater than 95%). View All» Storage Conditions: See individual components for storage/handling conditions. View All» Components:

• This product contains the following components:

• Cat. # 05-1050X 4G10® Platinum, Anti-phosphotyrosine

• Cat. # 05-1000X Anti-Phosphoserine, Clone 4A4

• Click above links for formulation, storage/handling conditions and product specific images and certificates of analysis.
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunofluorescence

  • Flow Cytometry

  • Immunohistochemistry

  • ELISA

  • Immunocytochemistry
    View All» Qty/Pk: 1 kit View All» Brand Family: Upstate View All» Host: Mouse View All» Product Name: 4G10^® Platinum/4A4 Phosphopack View All»
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