货号：16-246

品牌：Merck Millipore

规格：125Ug

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor® 488 | 16-246 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG.Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor. View All» Specificity: external domain of EGF receptor on all human cells. Competes with EGF and TGF-α for binding on human cells. Recognizes both phosphorylated and non-phosphorylated human EGF receptors. View All» Immunogen: Human A431 membrane proteins View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Species Reactivity Note: Does not react with EGF receptors on mouse or rat cells. View All» Quality Assurance: Routinely evaluated by positive immunostaining for the EGF receptor in A431 cells. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: P00533 View All» Entrez Gene Number:

• NM_005228.3

• NM_201282.1

• NM_201283.1

• NM_201284.1
  View All» Gene Symbol:
  • EGFR

  • ERBB1

  • ERBB

  • mENA
    View All» Usage Statement:
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      View All» Key Applications: Immunofluorescence View All» UniProt Summary: FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.SIZE: 1210 amino acids; 134277 Da SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation." View All» Brand Family: Upstate View All» Product Name: Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor® 488 | 16-246 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 125 µg View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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