货号：14-911

品牌：Merck Millipore

规格：10Ug

目录价：￥5229.00

市场价格：￥4444.65

会员价格：￥4183.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Aurora C, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal 6His-tagged, recombinant, human Aurora C amino acids 35-end and N-terminal GST-tagged, recombinant, human INCENP, amino acids 821-end. Combined purity 94% by SDS-PAGE and Coomassie blue staining. Aurora C MW = 36kDa, INCENP MW = 38kDa. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role inorganizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. View All» UniProt Summary: Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Catalytic activity: ATP + a protein = ADP + a phosphoprotein.Cofactor: Magnesium.Enzyme regulation: Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-172 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.Subunit structure: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. View All» Species: Human View All» Molecular Weight: Aurora C MW = 36kDa, INCENP MW = 38kDa. View All» Brand Family: Upstate View All» Source: Co-expressed by baculovirus in Sf21 insect cells. View All» Storage Conditions: 6 months at -70°C View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• AIK32 3

• ARK-3

• STK13

• ARK3

• AurC
  View All» Product Name: Aurora C, active View All» Quality Assurance: Routinely evaluated by phosphorylation of substrate peptide View All» UniProt Number: Q9UQB9 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250µg size as catalog # 14-911M - Call for pricing and availability. View All» Entrez Gene Number: NP_001015878 View All» Purification Method: Ni2+/NTA agarose View All»
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