货号：14-910

品牌：Merck Millipore

规格：1EA

目录价：￥11165.33

市场价格：￥9490.53

会员价格：￥8932.26

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI3K-C2γ View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GST-tagged recombinant human PI3K-C2γ amino acids 468–1203 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. View All» UniProt Summary: FUNCTION: In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.SUBCELLULAR LOCATION: Membrane; Peripheral membrane proteinTISSUE SPECIFICITY: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.SIMILARITY: Belongs to the PI3/PI4-kinase family. Contains 1 C2 domain. Contains 1 PI3K/PI4K domain. Contains 1 PX (phox homology) domain. View All» Species: Human View All» Molecular Weight: 112kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PI3K-C2γ View All» Presentation: 0.54mg/ml of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: PI3K/PI4K View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PI3-kinase

• PIK3

• PI3K

• PTDINS-3-kinase

• PI3K C2g

• PI3-Kinase Class II

• PIK3C2G
  View All» Product Name: PI3K-C2γ View All» Quality Assurance: Routinely evaluated in the PIProfiler. View All» UniProt Number: O75747 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size as catalog # 14-910M - Call for pricing and availability. View All» Entrez Gene Number: BC130277 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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