货号：14-902M

品牌：Merck Millipore

规格：

目录价：￥30125.00

市场价格：￥25606.25

会员价格：￥24100.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: AMPK (α2, β1, γ1), active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. View All» UniProt Summary: Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Catalytic activity: ATP + a protein = ADP + a phosphoprotein.Cofactor: Magnesium.Enzyme regulation: Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-172 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.Subunit structure: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. View All» Species: Human View All» Molecular Weight: AMPKα2 MW = 63 kDa, AMPKß1 MW = 30 kDa, AMPKγ1 MW = 38 kDa View All» Brand Family: Upstate View All» Source: Expressed in E. coli cells and activated in vivo. View All» Protein Target: AMPK (α2, β1, γ1) View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PRKAB1

• PRKAG1

• PRKAA2
  View All» Product Name: AMPK (α2, β1, γ1), active View All» Quality Assurance: Routinely evaluated by phosphorylation of substrate peptide View All» UniProt Number: P54646, Q9Y478, P54619 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-902) and in bulk (cat# 14-902-K). View All» Entrez Gene Number: NM_006252, NM_006253, NM_002733 View All» Purification Method: Cobalt-agarose View All»
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