货号：14-871

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: UbcH5b, recombinant View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: Recombinant fusion protein containing human UbcH5b with an N-terminal His-tag, expressed in E. coli. View All» Key Applications: Activity Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P62837 # Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.SIZE: 147 amino acids; 16735 Da SUBUNIT: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.SIMILARITY: SwissProt: P62837 ## Belongs to the ubiquitin-conjugating enzyme family. View All» Species: Human View All» Molecular Weight: 20 kDa View All» Brand Family: Upstate View All» Source: Expressed in E. coli. View All» Presentation: 100 µg recombinant UbcH5b in 100 µL of 50mM Tris-HCl, pH 7.5, 270mM Sucrose, 150mM NaCl, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.02% Brij-35, 0.2mM PMSF, and 1mM Benzamidine. Frozen solution. View All» Storage Conditions: Stable for 2 years at -70°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» Gene Symbol:

• UBE2D2

• UBCH5B

• PUBC1

• E2

• UbcH5B

• UBC4/5

• E2(17)KB2

• UBC4
  View All» Product Name: UbcH5b, recombinant View All» Quality Assurance: Routinely evaluated by ubiquitin assay View All» UniProt Number: P62837 View All» Entrez Gene Number:
  • NM_003339.2

  • NM_181838.1
    View All» Purity: ~85% by SDS PAGE and Coomassie blue staining. View All» Purification Method: ProBond Resin chromatography View All»
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