货号:14-840M
品牌:Merck Millipore
规格:1EA
目录价:¥76823.05
市场价格:¥65299.59
会员价格:¥61458.44
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Description:
AMPK (α1, β1, γ1), active
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
250 µg
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Product Overview:
Recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 and full length untagged AMPKγ1.
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Key Applications:
Kinase Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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Species:
Human
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Molecular Weight:
AMPKα1 MW = 64 kDa, AMPKß1 MW = 30 kDa, AMPKγ1 MW = 38 kDa
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Brand Family:
Upstate
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Source:
Expressed in E. coli cells and activated in vivo.
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Protein Target:
AMPK (α1, β1, γ1)
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Storage Conditions:
6 months at -70°C
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Target Sub-Family:
CAMK
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Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
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Gene Symbol:
-
PRKAB1
-
PRKAG1
-
PRKAA1
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Product Name:
AMPK (α1, β1, γ1), active
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Quality Assurance:
Routinely evaluated by phosphorylation of substrate peptide
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UniProt Number:
Q13131, Q9Y478, P54619
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Packaging:
Also available in 10 μg size (cat#14-840) and in bulk (cat# 14-840-K).
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Entrez Gene Number:
AF100763, NM_006253, NM_002733
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Purification Method:
Cobalt-agarose
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