货号：14-828

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HDAC4, active recombinant protein View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 each View All» Product Overview: Recominant human HDAC4 (a.a. 627-end) with N-terminal GST-tag View All» Background Information: Histone deacetylation acts a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC4 is a histone deacetylase which deacetylates lysines on the core histones. HDAC4 accumulates in the nuclei of myotubes, suggesting involvement in muscle differentiation. HDAC4 does not bind DNA directly but interacts with the myocyte enhancer factors Mef2a, Mef2c, and Mef2d. HDAC4 also interacts with the breast cancer-associated transcriptional repressor PLU-1/JARID1B, the Nr2c1/TR2 nuclear receptor, as well as the 14-3-3 chaperone protein, in a phosphorylation dependent manner. It also forms part of a multiprotein complex with RbAp48 and HDAC3. View All» Key Applications:

• Western Blotting

• Enzyme Assay
  View All» Application Notes: HDAC deacetylase assays View All» Species: Human View All» Molecular Weight: 49 kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf9 insect cells. View All» Presentation: 50 μg of recombinant protien in 50 mM Tris-HCl, pH 7.0, 150 mM NaCl, 0.1 mM EDTA, 1 mM dithiothreitol, 20% glycerol. View All» Storage Conditions: Store in aliquots at -70°C. Avoid freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing cap. View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Gene Symbol:
  • HD4

  • HDAC4
    View All» Product Name: HDAC4, active recombinant protein View All» Concentration: 0.2 mg/ml View All» Quality Assurance: HDAC4 Deacetylase Assay: 2 µg of this lot of enzyme deacetylated 100 µM assay substrate using the HDAC Assay Kit, Catalog # 17-356 View All» Physical Form: Frozen solution View All» Format: Purified View All» UniProt Number: P56524 View All» Specific Activity: [Varies with lot. For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.] Lot R0801D0003: 2.7 U/mg, where one unit of HDAC4 activity is defined as 1 nmol of assay substrate (HDAC assay kit, catalog #17-356) deacetylated per minute at 37°C. View All» Entrez Gene Number: NM_006037 View All» Purity: Purity >90% by SDS-PAGE and Coomassie blue staining. View All» Purification Method: Purified using glutathione-agarose. GST portion was cleaved by PreScission™ protease. View All»
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